Project 2 - Biosensors
Development of Rapid, Miniaturized Biosensors
Dr. Ian Kennedy, Professor of Mechanical & Aeronautical Engineering
Dr. Michael Denison, Professor of Environmental Toxicology
Dr. David Horsley, Associate Professor of Mechanical & Aeronautical Engineering
It is the goal of this project, Biosensors, to apply new and emerging technologies to implement bioassays that our colleagues at Davis have developed, with improvements in speed and/or sensitivity compared to conventional methods. Several new schemes for detection are being tested, including a nanowell format for trapping and interrogating our non-bleaching nanoparticle labels for DNA and immuno assays; a magnetic/luminescent nanoparticle format for DNA assays; and a nanostructured liquid core waveguide for enhancement of fluorescence detection. The targets will include the pyrethroid metabolite 3-PBA, emerging problem compounds such as TCC, TCS and PBDE, and genes for microbes that are used in bioremediation activities. A sensor for TCDD and related compounds are being l be developed based on AhR technology.