Hammock Laboratory of Pesticide Biotechnology

University of California

Hammock Laboratory of Pesticide Biotechnology

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Epoxide Hydrolase (2011-Current)

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778. Honetschlägerová, Z., Z Husková, Z. Vanourková, A. Sporková, H.J. Kramer, S.H. Hwang, H-J. Tsai, B.D. Hammock, J.D. Imig, L. Cervenka and L. Kopkan. 2011. Renal mechanisms contributing to the antihypertensive action of soluble epoxide hydrolase inhibition in Ren-2 transgenic rats with inducible hypertension. J. Physiol. 589(1):207-219.

780. Anandan, S-K., H.K. Webb, D. Chen, Y-X. Wang, B.R. Aavula, S. Cases, Y. Cheng, Z.N. Do, U. Mehra, V. Tran, J. Vincelette, J. Waszczuk, K. White, K.R. Wong, L-N. Zhang, P.D. Jones, B.D. Hammock, D.V. Patel, R. Whitcomb, D.E. MacIntyre, J. Sabry and R. Gless. 2011. 1-(1-Acetyl-piperidin-4-yl)-3-adamantan-1-yl-urea (AR9281) as a potent, selective, and orally available soluble epoxide hydrolase inhibitor with efficacy in rodent models of hypertension and dysglycemia. Bioorg. Med. Chem. Lett. 21(3):983-988. PMID: 21211973.

781. Charles, R.L., J.R. Burgoyne, M. Mayr, S.M. Weldon, N. Hubner, H. Dong, C. Morisseau, B.D. Hammock, A. Landar and P. Eaton. 2011. Redox regulation of soluble epoxide hydrolase by 15-Deoxy-?-Prostaglandin J2 controls coronary hypoxic vasodilation. Circ. Res. 108:324-334. PMID: 21164107. PMCID:PMC 3259859.

782. Schebb, N.H., B. Inceoglu, T. Rose, K. Wagner and B.D. Hammock. 2011. Development of an ultra fast online-solid phase extraction (SPE) liquid chromatography electrospray tandem mass spectrometry (LC-ESI-MS/MS) based approach for the determination of drugs in pharmacokinetic studies. Anal. Methods 3(2):420-428. PMID: 21660124. PMCID: PMC3110015.

783. Qiu, H., N. Li, J-Y. Liu, T.R. Harris, B.D. Hammock and N. Chiamvimonvat. 2010. Soluble epoxide hydrolase inhibitors and heart failure. Cardiovasc. Ther. 29(2):99-111. PMID: 20433684.

784. Li, N., J-Y. Liu, H. Qiu, T.R. Harris, P. Sirish, B.D. Hammock and N. Chiamvimonvat. 2011. Use of metabolomic profiling in the study of arachidonic acid metabolism in cardiovascular disease. Congest. Heart Fail. 17(1):42-46\. PMID: 21272227.

786. Aboutabl, M.E., B.N. Zordoky, B.D. Hammock and A.O. El-Kadi. 2011. Inhibition of soluble epoxide hydrolase confers cardioprotection and prevents cardiac cytochrome P450 induction by benzo(a)pyrene. J. Cardiovasc. Pharmacol. 57(3):273-281.

787. Kim, I.H., Y.K. Park, B.D. Hammock and K. Nishi. 2011. Structure – activity relationships of cycloalkylamide derivatives as inhibitors of the soluble epoxide hydrolase. J. Med. Chem. 54(6):1752-1761.

788. Inceoglu, B., K. Wagner, N.H. Schebb, C. Morisseau, S.L. Jinks, A. Ulu, C. Hegedus, T. Rose, R. Brosnan and B.D. Hammock. 2011. Analgesia mediated by soluble epoxide hydrolase inhibitors is dependent on cAMP. PNAS 108(12):5093-5097.

789. Koeners, M.P., S. Wesseling, A. Ulu, R.L. Sepúlveda, C. Morisseau, B. Braam, B.D. Hammock and J.A. Joles. 2011. Soluble epoxide hydrolase in the generation and maintenance of high blood pressure in spontaneously hypertensive Rats. Am. J. Physiol. Endocrinol. Metab. 300(4):E691-698. PMID: 21266668. PMCID: PMC3074945.

791. Wagner, K., B. Inceoglu, S.S. Gill and B.D. Hammock. 2011. Epoxygenated fatty acids and soluble epoxide hydrolase inhibition: Novel mediators of pain reduction. J. Agric. Food Chem. 59(7):2816-2824. PMID: 20958046.

792. Schebb, N.H., B. Inceoglu, K.C. Ahn, C. Morisseau, S.J. Gee and B.D. Hammock. 2011. Investigation of human exposure to triclocarban after showering and preliminary evaluation of its biological effects. Environ. Sci. Technol. 45(7):3109-3115.

793. Abdu, E., D.A. Bruun, D. Yang, J. Yang, B. Inceoglu, B.D. Hammock, N.J. Alkayed and P.J. Lein. 2011. Epoxyeicosatrienoic acids enhance axonal growth in primary sensory and cortical neuronal cell cultures. J.Neurochem. 117:632-642.

794. Hwang, S.H., K.M. Wagner, C. Morisseau, J-Y. Liu, H. Dong, A.T. Wecksler and B.D. Hammock. 2011. Synthesis and structure – activity relationship studies of urea-containing pyrazoles as dual inhibitors of cyclooxygenase-2 and soluble epoxide hydrolase. J. Med. Chem. 54(8):3037-3050. PMID: 21434686. PMCID: PMC3281519.

795. Schebb, N.H., M. Huby, C. Morisseau, S.H. Hwang and B.D. Hammock. 2011. Development of an online SPE-LC-MS-based assay using endogenous substrate for the investigation of soluble epoxide hydrolase (sEH) inhibitors. Anal. Bioanal. Chem. 400(5):1359-1366. PMID: 21479549. PMCID:PMC 3081056.

796. Barhoumi, R., Y. Mouneimne, E. Ramos, C. Morisseau, B.D. Hammock, S. Safe, A.R. Parrish and R.C. Burghardt. 2011. Multiphoton spectral analysis of benzo[a]pyrene uptake and metabolism in a rat liver cell line. Toxicol. Appl. Pharmacol. 253(1):45-56. PMCID: PMC3081912

797. Morisseau, C., M. Bernay, A. Escaich, J.R. Sanborn, J. Lango and B.D. Hammock. 2011. Development of fluorescent substrates for microsomal epoxide hydrolase and application to inhibition studies. Anal. Biochem. 414:154-162. PMID: 21371418. PMCID:PMC 3090455.

798. Yang, J., H. Dong and B.D. Hammock. 2011. Profiling the regulatory lipids: Another systemic way to unveil the biological mystery. Curr. Opin. Lipidol. 22(3):197-203. PMID: 21537174.

800. Luria, A., A. Bettaieb, Y. Xi, G-J. Shieh, H-C. Liu, H. Inoue, H-J. Tsai, J.D. Imig, F.G. Haj and B.D. Hammock. Soluble epoxide hydrolase deficiency alters pancreatic islet size and improves glucose homeostasis in a model of insulin resistance. PNAS 108(22):9038-9043.

801. Jiang, H., J. Quilley, A.B. Doumad, A.G. Zhu, J.R. Falck, B.D. Hammock, C.T. Stier Jr., and M.A. Carroll. 2011. Increases in plasma trans-EETs are associated with blood pressure reduction in spontaneously hypertensive rats. Am. J. Physiol Heart Circ Physiol. 300(6):H1990-1996. PMID: 21398593. PMCID: PMC3119086.

802. Sporkova, A., L. Kopkan, S. Varcabova, Z. Huskova, S.H. Hwang, B.D. Hammock, J.D. Imig, H.J. Kramer and L. Cervenka. 2011. Role of cytochrome P-450 metabolites in the regulation of renal function and blood pressure in 2-kidney 1-clip hypertensive rats. Am. J. Physiol. Regul. Integr. Comp. Physiol. 300(6):R1468-1475. PMID: 21411763. PMCID: PMC3119161.

804. Zivkovic, A.M., N. Telis, J.B. German and B.D. Hammock. 2011. Dietary omega-3 fatty acids in the modulation of inflammation and metabolic health. California Agr. 65:106-111.

805. Schebb, N.H., I. Flores, T. Kurobe, B. Franze, A. Ranganathan, B.D. Hammock and S. Teh. 2011. Bioconcentration, metabolism and excretion of triclocarban in Qurt medaka (Oryzias latipes). Aquatic Toxicology. 105(3-4): 448– 454. PMID: 21872556. PMCID: PMC3236035.

806. Liu, X., C. Li, S.H. Hwang, B.D. Hammock, J.R. Falck, R.J. Roman, D.R. Harder and R.C. Koehler. 2011. Epoxyeicosatrienoic acid-dependent cerebral vasodilation evoked by metabotropic glutamate receptor activation in vivo. American J Physiology: Heart and Circulatory Physiology. 301(2):H373-81. PMCID: PMC3154671.

807. Hasenau, A.L., G. Nielsen, C. Morisseau, B.D. Hammock, H. Wulff and R. Köhler. 2011. Improvement of endothelium-dependent vasodilations by SKA-31 and SKA-20, activators of small- and intermediate conductance Ca(2+)-activated K(+)-channels. Acta Physiol. (Oxf). 203(1):117–126. PMID: 21362152. PMCID: PMC3139805.

809. Hammock, B.D., K. Wagner, and B. Inceoglu. 2011. The soluble epoxide hydrolase as a pharmaceutical target for pain management. Pain Manage. 1(5): 383-386.

810. Yin, Z., V. Pintea, Y. Lin, B.D. Hammock and M.A. Watsky. 2011. Vitamin D enhances corneal epithelial barrier function. Invest. Ophthalmol.Vis. Sci. 52(10):7359-7364. PMID:21715350. PMCID: PMC3183972.

812. Honetschlägerová, Z, A. Sporková, L. Kopkan, Z. Husková, S.H. Hwang, B.D. Hammock, J.D. Imig, H.J. Kramer and L. ?ervenka. 2011. Inhibition of soluble epoxide hydrolase improves the impaired pressure-natriuresis relationship and attenuates the development of angiotensin II-dependent malignant hypertension in Cyp1a1-Ren-2 transgenic rats. J. Hypertens. 29(8):1590-1601. PMID: 21720266.

813. Davis, B.B., J.Y. Liu, D.J. Tancredi, L. Wang, S.I. Simon, B.D. Hammock and K.E. Pinkerton. 2011. The anti-inflammatory effects of soluble epoxide hydrolase inhibitors inhibitors are independent of leukocyte recruitment. Biochem. Biophys. Res. Commun. 410(3):494-500. PMID: 21683067. PMCID: PMC3166856.

816. Wagner, K., B. Inceoglu and B.D. Hammock. 2011. Soluble epoxide hydrolase inhibition, epoxygenated fatty acids and nociception. Prostaglandins and Other Lipid Mediat. 96(1-4)76-83. PMID: 21854866. PMID: 21854866. PMCID: PMC3215909.

817. Ionue, H., S.H. Hwang, A.T. Wecksler, B.D. Hammock and R.H. Weiss. 2011. Sorafenib attenuates p21 in kidney cancer cells and augments cell death in combination with DNA-damaging chemotherapy. Cancer Biol Ther. 12(9):827-36. PMID:21878748.

818. Yang, Jun, H. Dong, B.D. Hammock. 2011. EETs and oxo-ETE in airway diseases. In: Obstructive Airway Disease. Role of Lipid Mediators. pp.125-150. CRC Press.

823. Ulu, A., S.E. Appt, C. Morisseau, S.H. Hwang, P.D. Jones, T.E. Rose, H. Dong, J. Lango, J. Yang, H.J. Tsai, C. Miyabe, C. Fortenbach, M.R. Adams and B.D. Hammock. 2012. Pharmacokinetics and in vivo potency of soluble epoxide hydrolase inhibitors in cynomolgus monkeys. Br J Pharmacol. 165(5):1401-12. PMID:21880036.

824. Pecic, S., S.X. Deng, C. Morisseau, B.D. Hammock and D.W. Landry. 2012. Design, synthesis and evaluation of non-urea inhibitors of soluble epoxide hydrolase. Bioorg Med Chem Lett. 22(1):601-5. PMID: 22079754.

825. Panigrahy, D.,M.L. Edin, C.R. Lee, S. Huang, D.R. Bielenberg, C.E. Butterfield, C.M. Barnés, A. Mammoto, T. Mammoto, A. Luria, O. Benny, D.M. Chaponis, A.C. Dudley, E.R. Greene, J.A. Vergilio, G. Pietramaggiori, S.S. Scherer-Pietramaggiori, S.M. Short, M. Seth, F.B. Lih, K.B. Tomer, J. Yang, R.A. Schwendener, B.D. Hammock, J.R. Falck, V.L. Manthati, D.E. Ingber, A. Kaipainen, P.A. D’Amore, M.W. Kieran and D.C. Zeldin. 2012. Epoxyeicosanoids stimulate multiorgan metastasis and tumor dormancy escape in mice. J Clin Invest. 122(1):178-91. PMID: 22182838. PMCID: PMC3248288.

826. Hou, H.H., B.D. Hammock, K.H. Su, C. Morisseau, Y.R. Kou, S. Imaoka, A. Oguro, S.K. Shyue, J.F. Zhao and T.S. Lee. 2012. N-terminal domain of soluble epoxide hydrolase negatively regulates the VEGF-mediated activation of endothelial nitric oxide synthase. Cardiovasc Res. 93(1):120-9. PMID: 22072631. PMCID: PMC3243038.

828. Landeros, R.V., C. Morisseau, H.J. Yoo, S.H. Fu, B.D. Hammock and B.C. Trainor. 2012. Corncob bedding alters the effects of estrogens on aggressive behavior and reduces estrogen receptor alpha expression in the brain. Endocrinology. 153(2):949-53. PMID: 22186416. PMCID: PMC 3275391.

830. Lundström, S.L. , B. Levänen, M.L. Nording, A. Klepczynska-Nyström, M. Sköld, J.Z Haeggström, J. Grunewald, M. Svartengren, B.D. Hammock, B-M. Larsson, A. Eklund, C.E Wheelock and Å.M. Wheelock. 2011. Asthmatics exhibit altered oxylipin profiles compared to healthy individuals after subway air exposure. PLoS One. 6(8):e23864. PMID: 21897859. PMCID: PMC 3163588.

831. Neckár, J., L. Kopkan, Z. Husková, F. Kolár, F. Papoušek, H.J. Kramer, S.H. Hwang, B.D. Hammock, J.D. Imig, J. Malý, I. Netuka, B. Oštádal and L. Cervenka. 2012. Inhibition of soluble epoxide hydrolase by cis-4-[4-(3-adamantan-1-yl-ureido)-cyclohexyl-oxy]-benzoic acid exhibits antihypertensive and cardioprotective actions in transgenic rats with angiotensin II-dependent hypertension. Clin.Sci (Lond). 122(11):513-25. PMID: 22324471.

832. Iyer, A., K. Kauter, M.A. Alam, S.H. Hwng, C. Morisseau, B.D. Hammock and L. Brown. 2012. Pharmacological inhibition of soluble epoxide hydrolase ameliorates diet-induced metabolic syndrome in rats. Exp Diabetes Res. 2012:758614. PMID:22007192. PMCID: PMC3191770.

833. Shen, H., and B.D. Hammock. 2012. Discovery of inhibitors of soluble eoxide hydrolase: a target with multiple potential therapeutic indications. J Med Chem. 55(5):1789-808. PMID: 22168898.

834. Helferich, W.G., M.H. Silva, W.T. Flueck, B.D. Hammock and L.R. Shull. 1987. Xenobiotic biotransformation in livers and lungs of adult black-tailed deer: comparison with domestic goat and sheep. Comp Biochem Physiol C. 88(1):145-49. PMID: 2890476.

835. Lundström, S.L., J. Yang, H.J. Kallberg, J.Z. Haeggstrom, M. Nord, R. Gronneberg, J. Grunewald, M. Van Hage, B.D. Hammock, A. Eklund, A.M. Wheelock and C.E. Wheelock. 2012. Allergic asthmatics show divergent lipid mediator profiles from healthy controls both at baseline and following birch pollen provocation. PLoS One. 7(3):e33780.

836. Duan, H.Y., K. Yoshimura, N. Kobayashi, K. Sugiyama, J. Sawada, Y. Saito, C. Morisseau, B.D. Hammock and T. Akatsuka. 2012. Development of monoclonal antibodies to himan microsomal epoxide hydrolase and analysis of preneoplastic antigen-like molecules. Toxicol Appl Pharmacol. 260(1):17-26. PMID: 22310175. PMCID: PMD3319115.

837. Duan, H.Y., A. Takagi, H. Kayano, I. Koyama, C. Morisseau, B.D. Hammock and T. Akatsuka. 2012. Monoclonal antibodies reveal multiple forms of expression of human microsomal epoxide hydrolase. Toxicol Appl Pharmacol. 260(1):27-34. PMID: 22306621. PMCID: PMC3319120.

838. Zhang D., X. Xie, Y. Chen, B.D. Hammock, W. Kong and Y. Zhu. 2012. Homocysteine upregulates soluble epoxide hydrolase in vascular endothelium in vito and in vivo. Circ Res. 110(6):808-17. PMID: 22354938.

839. Schebb, N.H., K.C. Ahn, H. Dong, S.J. Gee and B.D. Hammock. 2012. Whole blood is the sample matrix of choice for bio-monitoring of human triclocarban exposure. Chemosphere. 87(7):825-27. PMID: 22273184.

840. Morisseau, C., N.H. Schebb, H. Dong, A. Ulu, P.A. Aronov and B.D. Hammock. 2012. Role of soluble epoxide hydrolase phosphatase activity in the metabolism of lysophosphatidic acids. Biochem Biophys Res Commun. 419(4):796-800. PMID: 22387545.

842. Zolkowska, D., C.N. Banks, A. Dhir, B. Inceoglu, J.R. Sanborn, M.R. McCoy, D.A. Bruun, B.D. Hammock, P.J. Lein and M.A. Rogawski. 2012. Characterization of seizures induced by acute and repeated exposure to etramethylenedisulfotetramine. J Pharmacol Exp Ther. 341(2):435-46. PMID: 22328574.

843. Wang, L., J. Yang, L. Guo, D. Uyeminami, H. Dong, B.D. Hammock and K.E. Pinkerton. 2012. Use of a soluble epoxide hydrolase inhibitors in smoked-induced chronic obstructive pulmonary disease. Am J Respir Cell Mol Bio. 46(5):614-22. PMID: 22180869.

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Page Last Updated: May 10, 2012

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